Exciting new cellular and molecular biology research
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The biology of extracellular vesicles: The known unknowns
Leonid Margolis, Yoel Sadovsky
UNSOLVED MYSTERY
Over a century of cancer research: Inconvenient truths and promising leads
Carlos Sonnenschein, Ana M. Soto
ESSAY
A proteomic atlas of senescence-associated secretomes for aging biomarker development
Nathan Basisty, Abhijit Kale, Ok Hee Jeon, Chisaka Kuehnemann, Therese Payne, et al
Methods & Resources
→ Published peer review history
Islands of retroelements are major components of Drosophila centromeres
Ching-Ho Chang, Ankita Chavan, Jason Palladino, Xiaolu Wei, Nuno M. C. Martins, et al
RESEARCH ARTICLE
Snail synchronizes endocycling in a TOR-dependent manner to coordinate entry and escape from endoreplication pausing during the Drosophila critical weight checkpoint
Jie Zeng, Nhan Huynh, Brian Phelps, Kirst King-Jones
RESEARCH ARTICLE
Primary cilium loss in mammalian cells occurs predominantly by whole-cilium shedding
Mary Mirvis, Kathleen A. Siemers, W. James Nelson, Tim P. Stearns
SHORT REPORT
A widespread family of heat-resistant obscure (Hero) proteins protect against protein instability and aggregation
Kotaro Tsuboyama, Tatsuya Osaki, Eriko Matsuura-Suzuki, Hiroko Kozuka-Hata, Yuki Okada, et al
RESEARCH ARTICLE
→ Published peer review history
CRISPR screening using an expanded toolkit of autophagy reporters identifies TMEM41B as a novel autophagy factor
Christopher J. Shoemaker, Tina Q. Huang, Nicholas R. Weir, Nicole J. Polyakov, Sebastian W. Schultz, Vladimir Denic
METHODS AND RESOURCES
LOOKING AHEAD
Nonia Pariente, on behalf of the PLOS Biology Staff Editors Editorial